???? ?? ??? ???? ?? ??? ???? ??? ??? ????. ??? ??? ???? ???? ??? ???? ??? ? ?? ????? ??, ?? ???! ??? ?? ?? ??? ?? ???? ???? ????? ??? ?? ?? ??? ??? ??? ???, ?? ?? ??? ?? ???? ?? ??? ??? ???.?? ? ?? ??? ???? ??? ?? ?? ?? ???? ? ??? ???? ???? ???? ??? ???? ? ?? ??.??? ?? ??: ????? ?? ??? ???? ??? ??? ??? ?????.?? ???? ???? ???? ? ??? ??? ? ??? ???, ?

In 2014, a radical regulatory reform in Japan occurred Using the passing of two new guidelines that permitted conditional approval of cell-primarily based remedies subsequent early phase clinical trials within the condition that medical basic safety facts are supplied from not less than 10 sufferers. These legislation enable skipping the majority o

??? ?? ???? ???(??? ?? ???? ??)? ????? ????? ??????? ?? ???? ???? ???? ?? ?? ?? ??? ??? ?? ? ???, ??? ????? ??? ? ????.??? ??? ??? ????? ????, ????? ??? ???? ?? ?? ??? ??? ????. ???? ?? ??? ?? ?? ??? ? ???, ??? ??? ????? ?? ??? ??? ?????.??? ? ????? ???? ?????? ???? ?? ?? ??? ???? ??, ???, ???? ????? ????? ?? ???.- ?? ??? ?? ??? ?? ?? ? ???? ?? ? ?

??, ????? ?? ?? ???? ?? ??? ????, ??? ?? ??? ???? ??????. ?? ???? ?? ??? ??????? ?? ??: ???? ?? ??? ?? ??? ?? ??? ??? ??? ??? ????? ???. ??? ???? ??? ??? ???? ??? ??? ????? ??? ??? ???.????? ??? ??? ??? ?????. ?? ?? ???? ????? ??? ????? ?????? ??? ??????.? ?????? ???? ???? ???. ??? ??? ???? ???? ??? ????? ?? ?? ??. ???? ?? ???? ?? ???? ????? ??? ??

??? ??? ?? ? ??????? ???? ???? ?? ?? ???? ? ????.?????? ??? ?? ?? ?????? ??? ?? ??? ????? ???????.??? ? ?? ??? ??? ?? ????? ???? ???? ??? ??? ??? ?? ??????? ???.?? ??? ??? ??? ???? ????? ???? ?? ??? ???? ??? ? ????.? ???? ????? ??, ??, ??? ?? ? ??? ??? ?????. ?????? ???? ??? ???? ?? ??? ??? ???? ???? ??? ??? ?? ??? ??? ?? ? ????.??? ??? ???? ??? ?